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"O pneumococo é uma das principais causas de meningite nas crianças até aos 2 anos de idade. A proximidade com outras crianças é uma das formas de contágio da meningite pneumocócica, que é de todas as meningites a que poderá causar os maiores e mais graves danos cerebrais, motores e até mesmo levar à morte. Informe-se junto do seu médico."

Um conselho de: Sociedade Portuguesa de Pediatria.

ESCOLHA DE COMPARADORES NOS RCT

Esta semana, no NEJM_link.

Voltamos ás velhas questões da IF.

Porque é que para cada patologia os comparadores activos não são definidos por uma entidade independente?? Será assim tão dificil?

ESTATINAS

Equally interesting is why about half of people prescribed a statin stop taking it by about a year. Anecdotally, Bandolier hears that diarrhoea is responsible, but can find no studies to support this, or much at all on common adverse events with statins. Does anyone out there know better?

Bandolier Journal

Familial Hypercholesterolemia: a new start?

link@NEJM
Results All patients tolerated titration to the highest dose, 1.0 mg per kilogram per day. Treatment at this dose decreased low-density lipoprotein (LDL) cholesterol levels by 50.9% and apolipoprotein B levels by 55.6% from baseline (P<0.001 for both comparisons). Kinetic studies showed a marked reduction in the production of apolipoprotein B. The most serious adverse events were elevation of liver aminotransferase levels and accumulation of hepatic fat, which at the highest dose ranged from less than 10% to more than 40%.

Conclusions Inhibition of the microsomal triglyceride transfer protein by BMS-201038 resulted in the reduction of LDL cholesterol levels in patients with homozygous familial hypercholesterolemia, owing to reduced production of apolipoprotein B. However, the therapy was associated with elevated liver aminotransferase levels and hepatic fat accumulation.