Effect of Atorvastatin on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel in Healthy Subjects

Já que o Pocoyo começou... vamos lá ver o que têm a dizer deste ensaio clínico. Para mim é, à primeira abordagem, para rir... e sai publicado na Pharmacotherapy....

Effect of Atorvastatin on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel in Healthy Subjects

Study Objective. To investigate the potential effect of atorvastatin 80 mg/day on the pharmacokinetics and pharmacodynamics of the thienopyridines prasugrel and clopidogrel.
Design. Open-label, randomized, crossover, two-arm, parallel-group study.
Setting. Single clinical research center in the United Kingdom.
Participants. Sixty-nine healthy men aged 18–60 years.

http://www.atypon-link.com/PPI/doi/abs/10.1592/phco.28.12.1483

Cumprimentos, JFP